natinuel cataloge

Is an innovative bioceutic with strong dermal activity. It contains specific active substances derived from the latest biotechnology and advanced studies on skin aging Their synergy of action provides the skin with biochemical components required to activate a complete regeneration and restructuring of the ECM (Extracellular Matrix) of the dermis.

• Improves skin density.
• Improves tonicity and color of the the skin.
• Anti-wrinkle structural action.
• Protects the skin from free radicals, MMPs and glycation.
• Facial features become smoother.
• Maintains proper moisturization level.
• Strengthens cell cohesion, preventing the natural and physiological disintegration.

CARNOSINE+SILYBUM MARIANUM: Stops oxidative damage, blocks glycation reactions by inhibiting the RCS, counteracts the formation of protein cross-links.

OLIOGOPEPTIDE 20: Protects the skin from photo-aging damage. Maintains the MMP activity at a normal level. Protects and strengthens collagen from UV-induced damage and protects elastic fibers by inhibiting MMP 2 and MMP 9.

TRIPEPTIDE 3: A small peptide with triple action: Strongly stimulates the neo-collagen production through the activation of TGF-Beta (the key to fibroblasts activation). Protects the collagen by inhibiting MMPS 1-3. Locks pro-inflammatory cytokines.

RECONSTITUING NMF: The NMF plays an important role in the skin hydration and its deficiency results in water loss in the Stratum Corneum – approximately 25% and reduction in its elasticity – approximately 66%. It’s composed of a mixture of substances with strong hygroscopic properties which increase water retention in the stratum corneum making it more flexible and soft.

TETRAPEPTIDE-11: It stimulates the Syndecan-1 (a proteoglycan) synthesis to strengthen epidermal cohesion. It stimulates the synthesis of collagen XVII, improving the cohesion of epidermis cells. It stimulates keratinocytes growth.

UVA-UVB SOLAR FILTERS MIX: Selected medium SPF filters with high photostability and skin tolerance, guarantee complete protection against UVA UVB.

Is a specific bioceutic serum with double action, it contains a pool of new bio-active substances able to interact synergistically and sectorially with the substances constituting the Dermo-Epidermal Junction (DEJ). Improves the tone, elasticity, firmness of the skin and skin texture, gives an immediate and long-lasting effect of cosmetic lifting, gives an immediate effect of facial features relaxing.

• Increased cell cohesion.
• Increased tone and skin elasticity.
• Increasing the thickness of the dermis and in the deep layers of the epidermis.
• DEJ Restructuring.
• Improvement of skin firmness and compactness.
• Wrinkles are more relaxed and less obvious.
• Strong and long-lasting effect of cosmetic lifting.

DIPEPTIDE 5 + 6: They react with many DEJ structural proteins, laminin 5, collagen IV- VII-XVII, integrin, stimulating their regeneration, thereby improving the firmness and cell communication.

TETRAPEPTIDE-3: A specific peptide able to restructure the DEJ. It improves cell cohesion and contributes to the biological skin rejuvenation.

PEPHA TIGHT: A multifunctional component derived from biotechnology creating a relaxing surface densification. It provides an immediate long-lasting lifting effect and strengthens connective tissue. It also Improves neo-formation of type I collagen.

VIT. E (Alpha-Tocopherol): Intense biological antioxidant forming a part of the endogenous antioxidant system. In the presence of the A-tocopherol, the radicals which are generated during the lipoperoxidation combine with a-tocopherol rather than with the other fatty acids. This phenomenon terminates the chain of reactions because the tocopherol RL resulting unable to attack adjacent fatty acid chains.

Specific bioceutic delivering strong effect special functional ingredients being the the result of complex biotechnological processes give the product special properties thanks to which the product can reduce the functional deficit caused by hormonal changes that occur with time. It promotes the anabolic and regenerative mechanisms.

• Improves skin density and plasticity.
• Improves skin tonicity and skin color uniformity.
• Anti-wrinkle structural action.
• Protects against free radicals, MMPs increase and Glycation.
• Redefined facial features.
• Maintains skin moisture.

COMPENSATES THE HORMONE DEFICIENCY occurring ESPECIALLY IN MENOPAUSE.

GENISTEIN: Inhibits the protein tyrosine kinase and interrupts the consequential bio-chemical cascade signals. This action prevents collagen degradation and reduction of new collagen production. Genistein as an estrogen receptor agonist improves skin anabolic mechanisms.

CARNOSINE+SILYBUM MARIANUM: Stops oxidative damage, blocks glycation reactions by inhibiting the RCS, counteracts the formation of protein cross-links.

BIOMIMETIC TETRAPEPTIDE: Improves skin elasticity and resilience. It protects the elastic fibers by inhibiting elastase and stimulates the synthesis of type I collagen.

UVA-UVB SOLAR FILTERS MIX: Selected medium SPF filters with high photostability and skin tolerance, guarantee complete protection against UVA UVB.

Unique anti-aging cream providing comprehensive treatment fights all signs of aging.functional, such as dry skin, spots, inefficient skin barrier; and structural such as ptosis wrinkles, and enlarged pores. The anti-aging, anti-stress and protective effect is the result on telomers stabilization and preservation of the DNA (cell division) integrity. The improved skin quality is given by optimal cellular interactions (cell communication) and balancing its anabolic and catabolic processes.

Delays skin aging and prolongs cell life by1/3. Has smoothing and re-modulation properties increasing epidermal cell turnover, eliminates fine lines and gradually reduces deeper wrinkles. It improves elasticity, tone and firmness of the skin, restructures and reorganizes the Dermis and DEJ, makes the skin surface texture more homogenous and compact. It also counteracts collagen and elastin degradation and degeneration, blocks the free radical damage, protects cells from UV damage and improves skin moisturizing.

DIPEPTIDE-3: It biochemically mediates in corneodesmosomes binding, regulates cell turnover in the stratum corneum thus helping to maintain youth. This improves proliferation and differentiation of keratinocytes.

PENTAPEPTIDE-4: It is a matrikin peptide, which strongly stimulates fibroblasts and activates production of collagen and elastin, it promotes reparative processes in the dermis.

TRIPEPTIDE-10+TRIPEPTIDE-1: This peptides combination works in three different stages of the collagen lifecycle: SYNTHESIS, RE-ORGANIZATION AND PROTECTION. It increases the synthesis of type I-II-IV, regularizes the space between and the size of collagen fibrils, inhibits MMPs and prevents premature collagen destruction It also has anti-glycation properties.

RENOVAGE: Extends cellular lifespan, improves cellular metabolism, increases bio-protection of telomeres in cellular DNA.

SH-15 POLYPEPTIDE: Re-balance MMPs to physiological levels, it protects collagen and elastin from the premature demolition.

OLIGOPEPTIDE-20: Maintains healthy levels of MMPs, protects collagen and elastin structure from premature destruction.

CARNOSINE+SILYBUM MARIANUM: Stops oxidative damage, blocks glycation reactions by inhibiting the RCS, counteracts formation of cross-links between proteins.

LIPOIC ACID: A powerful antioxidant and hydroxyl, free radical scavenger. Lipoic acid is capable of preventing oxidation of ascorbic acid and inhibiting lipid peroxidation catalyzed by copper. It’s water and fat soluble which makes it possible to reach into different layers of the skin.

SOLAR FILTERS: Medium protection against UVA-UVB.

Product designated for skin with intensive inflammation, areas, and couperose.The cream formula was developed in such away that all the ingredients by interacting with one-another, can influence different aspects of a problem and favour skin normalisation. Known to normalize inflammatory processes, it reduces the expansion of the blood vessels and microvascular permeability, helps to strenghten capillary walls, decreases skin sensitivity to temperature changes.

• Effectively prevents the couperose problem.
• Normalizes extensive microcirculation extension.
• Thickens capillary walls.
• Clearly reduces redness, including chronic redness.
• Helps to prevent rosacea development.
• Reuces skin sensitivity to temperature changes.
• Strenghtens the skin barrier.

VPG-FACTOR S15 – exclusively Natinuel: Allows to retain the integrity of capillary vessels, nourishes and improves the metabolic exchange between skin cells, improves cellular oxidation, helps to remove negative body waste products and toxins, allows to retain the integrity of capillary vessels by increasing the tolerance threshold of sensitive skin, decreases the skin reactivity for various types of stimuli, decreases the reactivity of skin nerves, reduces the feeling of pain and discomfort.

VITAMIN PP: Has the ability to raise the properties of the skin’s barrier by regulating sfingolipids production within the skin, especifically ceramides.

TRIPEPTIDE-8: Reduces the activity of proinflammatory cytokines, decreases the tendency to dilated blood vessels, edema and erythema, allows to maintain the proper threshold of skin sensitivity.

Is a delicate cream designed for dry, chapped skin with couperose. Synergy that works to normalise the skin and influences different aspects of a problem. It strengthens capillary walls increasing the skin’s resistance to harmful external aggressions. The cream decreases the skin’s sensitivity to temperature jumps. Moreover, it helps the skin regain its optimal and longlasting level of moisture, either on the surface and on the deeper levels. It facilitates skin barrier restoration.

• Makes your skin become smooth, moist and rejunevated.
• Increases the skin’s resistance to harmful external aggressions.
• Strenghtens the skin’s barrier function.
• Makes skin texture smooth.
• Capillary vessels and red marks become less visible.
• Decreases the skin’s sensitivity.

DIPEPTYDE-1: Biological skin stabilizer which changes its apperance, promotes the release of beta- endorfines, facilitates the release of neurotransmitters responsible for the skin tension.

VENUCEANE: ItprotectsthecellstructurefromdamagingUVradiation, strengthenstheskinintegrity, prevents photo-aging, reduces TEWL, stimulates repair and prevention mechanisms.. It improves the keratinocyte differentiation and increases ceramide production.

HYDRAPROTECTOL-SM: Provides immediate skin moisture, improves deep moisture, strenghtens the skin’s resistance barrier.

PHOSPHATYDYLOCHOLINE: The molecule composed of necessary fatty acids of physico-chemical properties resembling those of lipids of the outermost layer of the skin, stratum corneum, increases the level of skin hydration and prevents TEWL as well as disorders of the cell interchange within the stratum corneum, reinforces the activity of skin’s barrier, helps to begin the epidermis repair process.

MELATONINE: An extremely potent antioxidant that helps to limit the influence of free radicals, hydroxyles and singlet oxygen. Protects the cells against harmful UV radiation, supports angiogenesis, stimulates neosinthesis of collagen and helps to retain the balance of metabollic processes.

RESWERATROL: Antioxidant and free radicals scavenger, anti-inflammatory action (inhibition of enzymes involved in mechanism of arachidonic acid action that activate the inflammatory process). It has an ability to stimulate cell proliferation and revitalize fibroblasts. It improves the neo-synthesis of collagen, inhibits proteases, protects cells from damaging UVB rays and improves microcirculation.

CERAMIDE-3: Contains a structure similar to ceramides of stratum corneum. Influences the trans- epidermal regulation of water flow, preventing its excessive loss, strenghtens the skin’s barrier against harmful external aggressions, improves cell cohesion.

SUNSCREENS: Average protection against UVA-UVB radiation.

Contains a certain number of new and innovative active ingredients. It preserves and restores the normal hydration level (in the superficial and deeper skin layers), improves the flexibility and compactness of stratum corneum, provides optimal protection against external aggressions.

THREE-PHASE HYDRATION:
• Corneus Layer, Vital Epidermis, Dermis.
• Regenerates and strengthens the skin barrier.
• Enhances protection from external aggressions.
• Prevents irritation due to poor hydration.

HYDRAPROTECTOL-SM: Rapidly improves superficial hydration and gradually improves moisturization of deeper skin layers. It strengthens the skin barrier.

NSLE: Highly dermo-compatible formula. It helps regenerate the lipid film and makes the skin more resistant to external aggressions.

TREALIX COMPLEX: Osmo-protector capable of combining with the molecules of water,and forming a homogenous mixture. It restores the NMF (Natural Moisturizing Factor).

PHYTIC ACID: It helps to prevent irritation and cell damage due to free radicals and alterations of the skin barrier. It strengthens skin to defend against external aggressions.

PHOSPHATIDYLCHOLINE: A molecule composed of essential fatty acids with chemical-physical properties similar to natural lipids of the stratum corneum. It increases the skin hydration level and prevents TEWL. It also prevents the stratum corneum cell turnover disorders, strengthens the skin barrier function, promotes epidermal regeneration.

SOLAR FILTERS: Medium protection against UVA-UVB.

Is the ideal product for maintaining a balanced cellular renewal of the epidermis which results in greater biological vitality of the skin and an improved aesthetic appearance. It helps maintain a proper skin barrier functioning and maintains and restores proper hydration level.

• Improves cell renewal.
• Increases bio-protection of the epidermis.
• It gives an immediate and intense hydration.
• Leaves the skin soft, firm, smooth, radiant and hydrated.

LIPOMOIST COMPLEX: A molecular film which is easily absorbed by the stratum corneum. Deep and long-lasting moisturizing action confers an immediate softness to the skin. It improves the epidermis ECM (Extra Cellular Matrix) cohesion, decreases TEWL (Excessive Water Evaporation), preserves the balance of lipids of the stratum corneum.

PHAs: (Gluconolactone, Lactobionic Acid ): It is found naturally in the skin as an important active substance in the cell renewal processes. In fact, the keratinocytes synthesize and naturally convert the gluconic acid and gluconolactone in ribose and deoxyribose, respectively fundamental RNA and DNA. Bases it has strong moisturizing properties. It ‘s a natural antioxidant which combats free radicals, it improves the barrier function of the skin, especially in sensitive skin and improves skin texture and protects from photoaging.

LACTOBIONIC ACID: It is an iron chelator, has a very powerful antioxidant action, has a strong hygroscopic power (properties of a substance to absorb water in liquid state that is the gaseous state). It’s a hyper-moisturizing, has a remarkable restorative activity promotes cellular renewal, modulates the keratinization. process. Increases epidermis firmness, help prevents and corrects the signs of skin aging.

Is a product developed for preserving the normal level of skin hydration. It regulates the TEWL level (evaporation) and is indicated for persistent dryness treatment, typical of the young and delicate skin.

• Immediately improves hydration.
• Improves medium-term hydration (12 – 24 hours).
• Improves the long-term hydration (up to 20 days).
• Improves cohesion of the epidermal extracellular matrix.
• Helps to reduce TEWL (Excessive Water Evaporation).
• Preserves lipid balance of the stratum corneum.

LIPOMOIST COMPLEX: A molecular film which is easily absorbed by the stratum corneum. Deep and long-lasting moisturizing action confers an immediate softness to the skin. Itimproves the epidermis ECM (Extra Cellular Matrix) cohesion, it helps to reduce TEWL (Excessive Water Evaporation) and preserves lipid balance of the stratum corneum.

SEA MOIST COMPLEX: Specially formulated combination of ingredients which has strong moisturizing properties and also facilitates the healing of dry skin. It Increases the structural integrity of the stratum corneum and enhances, biosynthesis functions of the epidermis.

UVA-UVB FILTERS: Guarantee a medium level protection against damaging effects of UV radiation without giving the skin an unpleasant white/blue effect, typical of many filters.