natinuel cataloge

Is a delicate cream designed for dry, chapped skin with couperose. Synergy that works to normalise the skin and influences different aspects of a problem. It strengthens capillary walls increasing the skin’s resistance to harmful external aggressions. The cream decreases the skin’s sensitivity to temperature jumps. Moreover, it helps the skin regain its optimal and longlasting level of moisture, either on the surface and on the deeper levels. It facilitates skin barrier restoration.

• Makes your skin become smooth, moist and rejunevated.
• Increases the skin’s resistance to harmful external aggressions.
• Strenghtens the skin’s barrier function.
• Makes skin texture smooth.
• Capillary vessels and red marks become less visible.
• Decreases the skin’s sensitivity.

DIPEPTYDE-1: Biological skin stabilizer which changes its apperance, promotes the release of beta- endorfines, facilitates the release of neurotransmitters responsible for the skin tension.

VENUCEANE: ItprotectsthecellstructurefromdamagingUVradiation, strengthenstheskinintegrity, prevents photo-aging, reduces TEWL, stimulates repair and prevention mechanisms.. It improves the keratinocyte differentiation and increases ceramide production.

HYDRAPROTECTOL-SM: Provides immediate skin moisture, improves deep moisture, strenghtens the skin’s resistance barrier.

PHOSPHATYDYLOCHOLINE: The molecule composed of necessary fatty acids of physico-chemical properties resembling those of lipids of the outermost layer of the skin, stratum corneum, increases the level of skin hydration and prevents TEWL as well as disorders of the cell interchange within the stratum corneum, reinforces the activity of skin’s barrier, helps to begin the epidermis repair process.

MELATONINE: An extremely potent antioxidant that helps to limit the influence of free radicals, hydroxyles and singlet oxygen. Protects the cells against harmful UV radiation, supports angiogenesis, stimulates neosinthesis of collagen and helps to retain the balance of metabollic processes.

RESWERATROL: Antioxidant and free radicals scavenger, anti-inflammatory action (inhibition of enzymes involved in mechanism of arachidonic acid action that activate the inflammatory process). It has an ability to stimulate cell proliferation and revitalize fibroblasts. It improves the neo-synthesis of collagen, inhibits proteases, protects cells from damaging UVB rays and improves microcirculation.

CERAMIDE-3: Contains a structure similar to ceramides of stratum corneum. Influences the trans- epidermal regulation of water flow, preventing its excessive loss, strenghtens the skin’s barrier against harmful external aggressions, improves cell cohesion.

SUNSCREENS: Average protection against UVA-UVB radiation.

Contains a certain number of new and innovative active ingredients. It preserves and restores the normal hydration level (in the superficial and deeper skin layers), improves the flexibility and compactness of stratum corneum, provides optimal protection against external aggressions.

THREE-PHASE HYDRATION:
• Corneus Layer, Vital Epidermis, Dermis.
• Regenerates and strengthens the skin barrier.
• Enhances protection from external aggressions.
• Prevents irritation due to poor hydration.

HYDRAPROTECTOL-SM: Rapidly improves superficial hydration and gradually improves moisturization of deeper skin layers. It strengthens the skin barrier.

NSLE: Highly dermo-compatible formula. It helps regenerate the lipid film and makes the skin more resistant to external aggressions.

TREALIX COMPLEX: Osmo-protector capable of combining with the molecules of water,and forming a homogenous mixture. It restores the NMF (Natural Moisturizing Factor).

PHYTIC ACID: It helps to prevent irritation and cell damage due to free radicals and alterations of the skin barrier. It strengthens skin to defend against external aggressions.

PHOSPHATIDYLCHOLINE: A molecule composed of essential fatty acids with chemical-physical properties similar to natural lipids of the stratum corneum. It increases the skin hydration level and prevents TEWL. It also prevents the stratum corneum cell turnover disorders, strengthens the skin barrier function, promotes epidermal regeneration.

SOLAR FILTERS: Medium protection against UVA-UVB.

Is the ideal product for maintaining a balanced cellular renewal of the epidermis which results in greater biological vitality of the skin and an improved aesthetic appearance. It helps maintain a proper skin barrier functioning and maintains and restores proper hydration level.

• Improves cell renewal.
• Increases bio-protection of the epidermis.
• It gives an immediate and intense hydration.
• Leaves the skin soft, firm, smooth, radiant and hydrated.

LIPOMOIST COMPLEX: A molecular film which is easily absorbed by the stratum corneum. Deep and long-lasting moisturizing action confers an immediate softness to the skin. It improves the epidermis ECM (Extra Cellular Matrix) cohesion, decreases TEWL (Excessive Water Evaporation), preserves the balance of lipids of the stratum corneum.

PHAs: (Gluconolactone, Lactobionic Acid ): It is found naturally in the skin as an important active substance in the cell renewal processes. In fact, the keratinocytes synthesize and naturally convert the gluconic acid and gluconolactone in ribose and deoxyribose, respectively fundamental RNA and DNA. Bases it has strong moisturizing properties. It ‘s a natural antioxidant which combats free radicals, it improves the barrier function of the skin, especially in sensitive skin and improves skin texture and protects from photoaging.

LACTOBIONIC ACID: It is an iron chelator, has a very powerful antioxidant action, has a strong hygroscopic power (properties of a substance to absorb water in liquid state that is the gaseous state). It’s a hyper-moisturizing, has a remarkable restorative activity promotes cellular renewal, modulates the keratinization. process. Increases epidermis firmness, help prevents and corrects the signs of skin aging.

Is a product developed for preserving the normal level of skin hydration. It regulates the TEWL level (evaporation) and is indicated for persistent dryness treatment, typical of the young and delicate skin.

• Immediately improves hydration.
• Improves medium-term hydration (12 – 24 hours).
• Improves the long-term hydration (up to 20 days).
• Improves cohesion of the epidermal extracellular matrix.
• Helps to reduce TEWL (Excessive Water Evaporation).
• Preserves lipid balance of the stratum corneum.

LIPOMOIST COMPLEX: A molecular film which is easily absorbed by the stratum corneum. Deep and long-lasting moisturizing action confers an immediate softness to the skin. Itimproves the epidermis ECM (Extra Cellular Matrix) cohesion, it helps to reduce TEWL (Excessive Water Evaporation) and preserves lipid balance of the stratum corneum.

SEA MOIST COMPLEX: Specially formulated combination of ingredients which has strong moisturizing properties and also facilitates the healing of dry skin. It Increases the structural integrity of the stratum corneum and enhances, biosynthesis functions of the epidermis.

UVA-UVB FILTERS: Guarantee a medium level protection against damaging effects of UV radiation without giving the skin an unpleasant white/blue effect, typical of many filters.

Is a specific product for three-phase hydration (Corneous Layer, Vital Epidermis, Dermis). It contains specific active ingredients which complement one another for a synergistic action that: Restores the physiological hydro-lipid film on the surface of the skin. Enhances the deep moisturizing treatment. Contributes to the normalization of sensitive, dry and uncomfortable skin. Strengthens the skin barrier against external aggressions. Suitable for very dehydrated skin.

• Repairs hydro-lipidic film of the skin.
• Regenerates the skin barrier.
• Restores the NMF level within the skin.
• Sebum-like effect.
• Promotes deep hydration.
• Helps to normalizes dry and sensitive skin.

HYDRAPROTECTOL-SM: Rapidly improves superficial hydration and gradually improves moisturization of deeper skin layers. It strengthens the skin barrier.

NSLE: Highly dermo-compatible formula, it helps regenerate the lipid film, and makes the skin more resistant to external aggressions.

TRIPEPTIDE: Enhances hyaluronic acid production and significantly improves hydration of the deeper layers of the skin.

Rich cream with growth factors exhibiting strong dermatological activity. It is able to stimulate a profound and complete renovation and regeneration of the epidermis, the dermis and the DEJ (Dermal-Epidermal Junction). Strong and specific bio-stimulation of fibroblasts is accompanied by action to regularize the micro-inflammation and degeneration of the main catabolic mechanisms such as MMPs and glycation, which are structurally extended and long lasting.

• Regeneration of the DEJ
• Regeneration of the ECM
• Optimization of the physiological state of the skin
• Optimization of epidermal regeneration with enhanced bio-functionality of stem cells
• Counteracts glycation and regulates MMPs.
• Optimizes the mechanisms of cutaneous repair

SURVIXYL Pentapeptide-31: A next-generation peptide that is a result of the latest discoveries in the field of stem cell research and is specifically designed to address five major factors that regulate the biological activity of the stem cells of the skin. It helps strengthen and preserve the microenvironment of stem cells and optimize epidermal rejuvenation.

G-FACTOR P63 – exclusively Natinuel: Activates differentiation of stem cells, promotes angiogenesis, increases biosynthesis of collagen, elastin, proteoglycans and GAGs, stimulates the skin’s self-repair mechanisms that reconstruct the skin’s protective barrier. Counteracts glycation of activated protein antioxidants such as SOD. Inhibits MMPs, blocks the activity of ‘interleukin-1.

aFGF (ACIDIC FIBROBLAST GROWTH FACTOR): fibroblast growth factors are key players in the processes of cell proliferation and differentiation. aFGF interacts with FGFR-2 activating rejuvenation of fibroblasts resulting in better production of collagen and elastin, hyaluronic acid with a general increase in dermal density. This activates regeneration of tissue damaged as a result of chrono and photo-aging.

bFGF (BASIC FIBROBLAST GROWTH FACTOR): Activates biological mechanisms responsible for regeneration and re-organization of the dermal extracellular matrix. Stimulates proliferation of fibroblasts, stimulates neocollagenogenesis and synthesis of new elastic fibers, stimulates production of glycosaminoglycans, increases fibronectin synthesis.

IDEBENON: Has a double action: blocks and eliminates free radicals generated by the environment, neutralizes free radicals generated internally, improves oxygenation and cellular energy.

HYACARE FILLER CL (Cross-linked Hyaluronic Acid): Has superior water-binding properties comparable to that of a super-absorbing polymer, has a high stability and resistance to enzymatic degradation. Micro-particles accumulate in puckering of the skin and wrinkles, creating a real filling effect.

Unique bio-functional complex product whoseoriginal formula radically changes the way of treating the aging skin, in particular problems connected with photo-aging. Interactive plus demonstrates strong multidirectional dermatological activity in anti- aging treatment. Its use allows us to reactivate simultaneously energetic, generative, protective and reparative biological processes affecting the Epidermis, Dermis and DEJ (Dermo-Epidermal Junction), for a total renovation and rejuvenation of the skin.

Increases collagen synthesis, activates fibroblasts, interact with specific receptors, has anti- oxidant, and anti-glycation properties and inhibits 2-9 MMPs. It has depigmentation, cellular bio-protection and anti-aging properties. It influences different anabolic and catabolic processes, activating strong DEJ and ECM (Extra-Cellular-Matrix) restructuring and epidermal regeneration for a total skin renewal.

BIOMIMETIC TRIPEPTIDE: It causes controlled weakening of the connections between cells. It recreates the natural desquamation process which usually occurs in young skin.

POLYHYDROXYACID: Presentintheskin, itisimportantincellrenewalprocesses, demonstrates strong moisturizing properties, modulates the process of keratinization, revitalizes cell turnover. It is also an antioxidant against ROS, improves the skin barrier function, especially in sensitive skin, protects your skin against photo-aging.

AHAs (Cycle-system): They activate the mechanisms that regulate cellular energy metabolism at the dermal-epidermal level(energizing)

MALIC ACID: Acts as a catalyst in the Krebs cycle, stimulates complete burning of energy rich substances.

RETINAL: Retinal is converted into retinoic acid and puts in place a real cellular reprogramming through actions of gene repression and derepression.

G-FACTOR P63 – exclusively Natinel: Activates differentiation of stem cells, promotes angiogenesis, increases biosynthesis of collagen, elastin, proteoglycans and GAGs, stimulates the skin repair mechanisms rebuilding the protective skin barrier, prevents glycation of proteins, activates removal of damaged skin proteins, activates antioxidant protein called SOD and MMPs inhibition, blocks the activity of interleukin-1.

IDEBENON: Is a dual action product, it blocks and removes free radicals generated by the environment, neutralizes free radicals generated internally, improves oxygenation and cellular energy.

DMAE: Improves skin firmness and muscle tone , increases the synthesis of collagen and elastin, it also has antioxidant properties.

Is a bio-functional complex exhibiting strong dermatological activity, its originality radically changes the “way” of treating skin aging. It is an innovative energizing metabolic agent, capable of ensuring deep activation and complete restructuring and regeneration of the “organ skin “. This Interactive Serum acts simultaneously on the biological mechanisms of energy, generative, protective and reparative epidermal level, Dermal and DEJ (Dermal-Epidermal Junction), a structural and long lasting.

• Increases collagen synthesis
• Activates fibroblasts
• Stimulates specific receptors
• Has anti-oxidant and anti-glycation properties and inhibit MMPs 2-9
• Has depigmentation, photo protection and anti-aging properties
• Prevents and counteracts photo-damage
• Turns on a major restructuring of DEJ is that the ECM(Extra Cellular Matrix) and skin renewal

BIOMIMETIC TRIPEPTIDE: Leads to a controlled weakening of the connections between the cells. Therefore, it reproduces the process of scaling typical of young skin.

PHA: Present in the skin is important in the processes of cell renewal, has strong moisturizing capacity, modulates the process of keratinization, revitalizes cell turnover, it is also an antioxidant against ROS, improves skin barrier function, especially in sensitive skin and protects against photoaging.

AHAs (Cycle-system): They are activators of the mechanisms that regulate cellular energy metabolism of dermal and -epidermal cells (energizing).

MALIC ACID: Acts as a catalyst in the Krebs’ cycle to, stimulate the complete combustion of fuel for energy.

RETINAL: Breaks down into retinoic acid and implements a real cellular reprogramming through actions of genes involved in repression and derepression.

G-FACTOR P63 – exclusively Natinuel: Activates the differentiation of stem cells, promotes angiogenesis, increases the biosynthesis of collagen, elastin, proteoglycans and GAGs, stimulates the self-repair mechanisms of the skin, rebuilds the protective barrier of the skin, counteracts the glycation of proteins, activates the removal of damaged skin proteins and activated protein antioxidants such as SOD, inhibits MMPs, blocks the activity of ‘interleukin-1.

IDEBENON : Has a double action: blocks and eliminates free radicals generated by the environment, neutralizes free radicals generated internally, improves oxygenation and cellular energy.

SURVIXYL Pentapeptide-31: A next-generation peptide that is a result of the latest discoveries in the field of stem cell research and is specifically designed to address five major factors that regulate the biological activity of the stem cells of the skin. It helps strengthen and preserve the microenvironment of stem cells and optimize epidermal rejuvenation.

Innovative professional product demonstrating broad-spectrum efficacy, containing substances with multiple revitalizing, moisturizing, bio-protective, and antioxidant properties. It is suitable for all skin types , even the most delicate and sensitive ones and can be used immediately before or after tanning or sun exposure. It ‘s particularly active in repairing and reactivating aging skin without causing discomfort such as stinging or reddening It immediately improves the brightness, smoothness and firmness of the skin, it is also suitable for treating acne, irritated skin and irregular pigmentation of the skin.

• Rejuvenation and revitalization of epidermal cells.
• Increases smoothness, brightness and firmness.
• Unifies and highlights the basic color of the skin.
• Significantly improves the quality and intensity of the tan.
• Improves hydration.
• Promotes rapid normalization of oily skin with enlarged pores and problematic skin.
• Normalizes skin irritations.

MANDELIC ACID: Modulator of epidermal cell turnover. The peel combines moisturizing and firming action. It unifies and highlights the basic color of the skin and immediately enhances skin radiance.

GLUCONOLACTONE + LACTOBIONIC ACID: It enhances strong moisturising effects, modulates the process of keratinization, revitalizes cell turnover, and is a natural antioxidant against free radicals.

MALIC ACID: Used as a Krebs cycle catalyst to stimulate the complete burning of fuel for energy.

PHYTIC ACID: Antioxidant, reduces lipid peroxidation. Chelating properties.

RESVERATROL: Antioxidant and free radicals scavenger (neutralizes ROS and RNS), anti- inflammatory action (inhibition of enzymes involved in mechanism of arachidonic acid action that activate the inflammatory process). It has an ability to stimulate cell proliferation and revitalize fibroblasts. It improves the neo-synthesis of collagen, inhibits proteases, protects cells from damaging UVB rays and improves microcirculation.

BOSWELIC ACID: Has a marked dual anti-inflammatory action: the first through the inhibition of the chemical mediators of the inflammatory processes. The second blocking the migration of leukocytes to the site of ‘inflammation. Moreover boswelic acid It helps to preserve correct levels of MMPs thus improving the biological condition of the dermis.