natinuel cataloge

Is an innovative bioceutic with strong dermal activity. It contains specific active substances derived from the latest biotechnology and advanced studies on skin aging Their synergy of action provides the skin with biochemical components required to activate a complete regeneration and restructuring of the ECM (Extracellular Matrix) of the dermis.

• Improves skin density.
• Improves tonicity and color of the the skin.
• Anti-wrinkle structural action.
• Protects the skin from free radicals, MMPs and glycation.
• Facial features become smoother.
• Maintains proper moisturization level.
• Strengthens cell cohesion, preventing the natural and physiological disintegration.

CARNOSINE+SILYBUM MARIANUM: Stops oxidative damage, blocks glycation reactions by inhibiting the RCS, counteracts the formation of protein cross-links.

OLIOGOPEPTIDE 20: Protects the skin from photo-aging damage. Maintains the MMP activity at a normal level. Protects and strengthens collagen from UV-induced damage and protects elastic fibers by inhibiting MMP 2 and MMP 9.

TRIPEPTIDE 3: A small peptide with triple action: Strongly stimulates the neo-collagen production through the activation of TGF-Beta (the key to fibroblasts activation). Protects the collagen by inhibiting MMPS 1-3. Locks pro-inflammatory cytokines.

RECONSTITUING NMF: The NMF plays an important role in the skin hydration and its deficiency results in water loss in the Stratum Corneum – approximately 25% and reduction in its elasticity – approximately 66%. It’s composed of a mixture of substances with strong hygroscopic properties which increase water retention in the stratum corneum making it more flexible and soft.

TETRAPEPTIDE-11: It stimulates the Syndecan-1 (a proteoglycan) synthesis to strengthen epidermal cohesion. It stimulates the synthesis of collagen XVII, improving the cohesion of epidermis cells. It stimulates keratinocytes growth.

UVA-UVB SOLAR FILTERS MIX: Selected medium SPF filters with high photostability and skin tolerance, guarantee complete protection against UVA UVB.

Is a specific bioceutic serum with double action, it contains a pool of new bio-active substances able to interact synergistically and sectorially with the substances constituting the Dermo-Epidermal Junction (DEJ). Improves the tone, elasticity, firmness of the skin and skin texture, gives an immediate and long-lasting effect of cosmetic lifting, gives an immediate effect of facial features relaxing.

• Increased cell cohesion.
• Increased tone and skin elasticity.
• Increasing the thickness of the dermis and in the deep layers of the epidermis.
• DEJ Restructuring.
• Improvement of skin firmness and compactness.
• Wrinkles are more relaxed and less obvious.
• Strong and long-lasting effect of cosmetic lifting.

DIPEPTIDE 5 + 6: They react with many DEJ structural proteins, laminin 5, collagen IV- VII-XVII, integrin, stimulating their regeneration, thereby improving the firmness and cell communication.

TETRAPEPTIDE-3: A specific peptide able to restructure the DEJ. It improves cell cohesion and contributes to the biological skin rejuvenation.

PEPHA TIGHT: A multifunctional component derived from biotechnology creating a relaxing surface densification. It provides an immediate long-lasting lifting effect and strengthens connective tissue. It also Improves neo-formation of type I collagen.

VIT. E (Alpha-Tocopherol): Intense biological antioxidant forming a part of the endogenous antioxidant system. In the presence of the A-tocopherol, the radicals which are generated during the lipoperoxidation combine with a-tocopherol rather than with the other fatty acids. This phenomenon terminates the chain of reactions because the tocopherol RL resulting unable to attack adjacent fatty acid chains.

Specific bioceutic delivering strong effect special functional ingredients being the the result of complex biotechnological processes give the product special properties thanks to which the product can reduce the functional deficit caused by hormonal changes that occur with time. It promotes the anabolic and regenerative mechanisms.

• Improves skin density and plasticity.
• Improves skin tonicity and skin color uniformity.
• Anti-wrinkle structural action.
• Protects against free radicals, MMPs increase and Glycation.
• Redefined facial features.
• Maintains skin moisture.

COMPENSATES THE HORMONE DEFICIENCY occurring ESPECIALLY IN MENOPAUSE.

GENISTEIN: Inhibits the protein tyrosine kinase and interrupts the consequential bio-chemical cascade signals. This action prevents collagen degradation and reduction of new collagen production. Genistein as an estrogen receptor agonist improves skin anabolic mechanisms.

CARNOSINE+SILYBUM MARIANUM: Stops oxidative damage, blocks glycation reactions by inhibiting the RCS, counteracts the formation of protein cross-links.

BIOMIMETIC TETRAPEPTIDE: Improves skin elasticity and resilience. It protects the elastic fibers by inhibiting elastase and stimulates the synthesis of type I collagen.

UVA-UVB SOLAR FILTERS MIX: Selected medium SPF filters with high photostability and skin tolerance, guarantee complete protection against UVA UVB.

A professional serum with high bio-activity. It contains a mixture of growth factors and specific peptides aimed at specific bio-stimulation and regeneration of the constituents of the DEJ (Dermo Epidermal Junction) and the ECM (extracellular matrix).

• Regeneration of the DEJ.
• Regeneration of the ECM.
• Optimization of the physiological state of the skin.
• Epidermal regeneration with enhanced bio-functionality of stem cells.

SYN-TACKS Peptide- 5, Dipeptide- 6: A peptide complex capable of interacting with key proteins of the DEJ, improving it both structurally and from a functional point of view, thus optimizing interchange between the epidermis and the dermis. Interacts with many structural proteins of the DEJ: laminin 5, collagen IV-VII-XVII, integrins stimulating regeneration. This translates into increased firmness, compactness, cellular communication.

SURVIXYL Pentapeptide-31: A next-generation peptide that is a result of the latest discoveries in the field of stem cell research and is specifically designed to target five major factors that regulate the biological activity of the skin stem cells . It helps strengthen and preserve the microenvironment of stem cells and optimize epidermal rejuvenation.

aFGF Acidis Fibroblast Growth Factor: The fibroblasts growth factors are key players in the processes of cell proliferation and differentiation. aFGF interacts with the FGFR-2 activating rejuvenation of fibroblasts, resulting in better production of collagen, elastin and hyaluronic acid with a general increase in dermal density. This activates regeneration of tissue damaged as a result of chrono and photo-aging.

bFGF Basic Fibroblast Growth Factor: Active biological mechanisms responsible for regeneration and of re-organization of the dermal extracellular matrix. Stimulates proliferation of fibroblasts, stimulates neocollagenogenesis and synthesis of new elastic fibers, stimulates production of glycosaminoglycans, and increases fibronectin synthesis.

Unique anti-aging cream providing comprehensive treatment fights all signs of aging.functional, such as dry skin, spots, inefficient skin barrier; and structural such as ptosis wrinkles, and enlarged pores. The anti-aging, anti-stress and protective effect is the result on telomers stabilization and preservation of the DNA (cell division) integrity. The improved skin quality is given by optimal cellular interactions (cell communication) and balancing its anabolic and catabolic processes.

Delays skin aging and prolongs cell life by1/3. Has smoothing and re-modulation properties increasing epidermal cell turnover, eliminates fine lines and gradually reduces deeper wrinkles. It improves elasticity, tone and firmness of the skin, restructures and reorganizes the Dermis and DEJ, makes the skin surface texture more homogenous and compact. It also counteracts collagen and elastin degradation and degeneration, blocks the free radical damage, protects cells from UV damage and improves skin moisturizing.

DIPEPTIDE-3: It biochemically mediates in corneodesmosomes binding, regulates cell turnover in the stratum corneum thus helping to maintain youth. This improves proliferation and differentiation of keratinocytes.

PENTAPEPTIDE-4: It is a matrikin peptide, which strongly stimulates fibroblasts and activates production of collagen and elastin, it promotes reparative processes in the dermis.

TRIPEPTIDE-10+TRIPEPTIDE-1: This peptides combination works in three different stages of the collagen lifecycle: SYNTHESIS, RE-ORGANIZATION AND PROTECTION. It increases the synthesis of type I-II-IV, regularizes the space between and the size of collagen fibrils, inhibits MMPs and prevents premature collagen destruction It also has anti-glycation properties.

RENOVAGE: Extends cellular lifespan, improves cellular metabolism, increases bio-protection of telomeres in cellular DNA.

SH-15 POLYPEPTIDE: Re-balance MMPs to physiological levels, it protects collagen and elastin from the premature demolition.

OLIGOPEPTIDE-20: Maintains healthy levels of MMPs, protects collagen and elastin structure from premature destruction.

CARNOSINE+SILYBUM MARIANUM: Stops oxidative damage, blocks glycation reactions by inhibiting the RCS, counteracts formation of cross-links between proteins.

LIPOIC ACID: A powerful antioxidant and hydroxyl, free radical scavenger. Lipoic acid is capable of preventing oxidation of ascorbic acid and inhibiting lipid peroxidation catalyzed by copper. It’s water and fat soluble which makes it possible to reach into different layers of the skin.

SOLAR FILTERS: Medium protection against UVA-UVB.

Product designated for skin with intensive inflammation, areas, and couperose.The cream formula was developed in such away that all the ingredients by interacting with one-another, can influence different aspects of a problem and favour skin normalisation. Known to normalize inflammatory processes, it reduces the expansion of the blood vessels and microvascular permeability, helps to strenghten capillary walls, decreases skin sensitivity to temperature changes.

• Effectively prevents the couperose problem.
• Normalizes extensive microcirculation extension.
• Thickens capillary walls.
• Clearly reduces redness, including chronic redness.
• Helps to prevent rosacea development.
• Reuces skin sensitivity to temperature changes.
• Strenghtens the skin barrier.

VPG-FACTOR S15 – exclusively Natinuel: Allows to retain the integrity of capillary vessels, nourishes and improves the metabolic exchange between skin cells, improves cellular oxidation, helps to remove negative body waste products and toxins, allows to retain the integrity of capillary vessels by increasing the tolerance threshold of sensitive skin, decreases the skin reactivity for various types of stimuli, decreases the reactivity of skin nerves, reduces the feeling of pain and discomfort.

VITAMIN PP: Has the ability to raise the properties of the skin’s barrier by regulating sfingolipids production within the skin, especifically ceramides.

TRIPEPTIDE-8: Reduces the activity of proinflammatory cytokines, decreases the tendency to dilated blood vessels, edema and erythema, allows to maintain the proper threshold of skin sensitivity.

Cream-mask designated for treatment of inflammatory skin, and skin with couperose. Its formula has been developed to immediately stabilize the skin which is intensely flushed. Active substances contained in the cream-mask have the influence on various biochemical processes being the cause of discomfort, crucial either from aesthetic or functional point of view. The mask has a double effect: after applying it can be washed away or stay until it absorbs into the skin by massaging delicately, as the cream finishing the treatment.

• Effectively prevents the couperose problem.
• Normalizes extensive microcirculation extension.
• Thickens capillary walls.
• Clearly reduces redness, including chronic redness.
• Helps to prevent acne development.
• Reduces skin sensitivity to temperature changes.
• Strengthens the skin barrier.

CHRYS 2B (Biotechnological Derivative of Chrysanthellum): Has intensive anti- inflammatory properties based on the blocade of chemical mediators of inflammation.

VEDACALMINE: Anti-inflammatory and moisturizing properties, which help to restore the hydrolipidic film by creating the protective layer, which reduces TEWL. Main ingredient of the complex is BOSWELIC ACID.

KARITE’ BUTTER: Contains very high fat content (from 12% up to 18%), necessary and basic for improving the skin elasticity, and in particular for retaining its standard flexibility.

CRYSTAL SKIN 1000: Biomimetic emulsion with the liquid crystal structure, dermocompatible with lipids from extracellular matrix, favours the integrity of the skin’s barrier.

Product designated for professional care – the skin with couperose, irritated red areas ofthe face with acne spots. The cream formula has been developed in such a way that all the ingredients by interacting with one another can influence different aspects of skin problem and favour skin normalisation. The product contains a mixture of active substances that facilitate normalisation of inflammatory processes, reduce the expansion of blood vessels and microvascular permeability, help to strenghten capillary walls and decrease skin sensitivity to changes in temperature.

• Effectively prevents the couperose problem.
• Normalizes extensive microcirculation extension.
• Thickens capillary walls.
• Clearly reduces redness, including chronic redness.
• Helps to prevent acne development.
• Reduces skin sensitivity to temperature changes.
• Strengthens the skin barrier.

VPG-FACTOR S15- exclusively Natinuel: Biomimetic complex, being a derivative of growth factors. Allows to achieve the complete vascular rebuild, has an anti-inflammatory and unsensitized effect, allows to save and recover integrity of capillaries, improves oxidation of the cells, increases the sensitive skin’s tolerance threshold, decreases the skin reactivity for various types of stimuli.

REGU-COMPLEX: Reduces red colouration of the skin, prevents irritations, blocks protease release. With its extraordinary soothing properties, it reduces telangiectasia condition.

CRYSTAL SKIN 1000: Dermocompatible formula containing lipids from extracellular matrix of cornified layer creates a wide cross-link area, which improves transpidermal release of soluble factors, and favours the integrity of skin barrier.