natinuel cataloge

Rich cream with growth factors exhibiting strong dermatological activity. It is able to stimulate a profound and complete renovation and regeneration of the epidermis, the dermis and the DEJ (Dermal-Epidermal Junction). Strong and specific bio-stimulation of fibroblasts is accompanied by action to regularize the micro-inflammation and degeneration of the main catabolic mechanisms such as MMPs and glycation, which are structurally extended and long lasting.

• Regeneration of the DEJ
• Regeneration of the ECM
• Optimization of the physiological state of the skin
• Optimization of epidermal regeneration with enhanced bio-functionality of stem cells
• Counteracts glycation and regulates MMPs.
• Optimizes the mechanisms of cutaneous repair

SURVIXYL Pentapeptide-31: A next-generation peptide that is a result of the latest discoveries in the field of stem cell research and is specifically designed to address five major factors that regulate the biological activity of the stem cells of the skin. It helps strengthen and preserve the microenvironment of stem cells and optimize epidermal rejuvenation.

G-FACTOR P63 – exclusively Natinuel: Activates differentiation of stem cells, promotes angiogenesis, increases biosynthesis of collagen, elastin, proteoglycans and GAGs, stimulates the skin’s self-repair mechanisms that reconstruct the skin’s protective barrier. Counteracts glycation of activated protein antioxidants such as SOD. Inhibits MMPs, blocks the activity of ‘interleukin-1.

aFGF (ACIDIC FIBROBLAST GROWTH FACTOR): fibroblast growth factors are key players in the processes of cell proliferation and differentiation. aFGF interacts with FGFR-2 activating rejuvenation of fibroblasts resulting in better production of collagen and elastin, hyaluronic acid with a general increase in dermal density. This activates regeneration of tissue damaged as a result of chrono and photo-aging.

bFGF (BASIC FIBROBLAST GROWTH FACTOR): Activates biological mechanisms responsible for regeneration and re-organization of the dermal extracellular matrix. Stimulates proliferation of fibroblasts, stimulates neocollagenogenesis and synthesis of new elastic fibers, stimulates production of glycosaminoglycans, increases fibronectin synthesis.

IDEBENON: Has a double action: blocks and eliminates free radicals generated by the environment, neutralizes free radicals generated internally, improves oxygenation and cellular energy.

HYACARE FILLER CL (Cross-linked Hyaluronic Acid): Has superior water-binding properties comparable to that of a super-absorbing polymer, has a high stability and resistance to enzymatic degradation. Micro-particles accumulate in puckering of the skin and wrinkles, creating a real filling effect.

Is a bio-functional complex exhibiting strong dermatological activity, its originality radically changes the “way” of treating skin aging. It is an innovative energizing metabolic agent, capable of ensuring deep activation and complete restructuring and regeneration of the “organ skin “. This Interactive Serum acts simultaneously on the biological mechanisms of energy, generative, protective and reparative epidermal level, Dermal and DEJ (Dermal-Epidermal Junction), a structural and long lasting.

• Increases collagen synthesis
• Activates fibroblasts
• Stimulates specific receptors
• Has anti-oxidant and anti-glycation properties and inhibit MMPs 2-9
• Has depigmentation, photo protection and anti-aging properties
• Prevents and counteracts photo-damage
• Turns on a major restructuring of DEJ is that the ECM(Extra Cellular Matrix) and skin renewal

BIOMIMETIC TRIPEPTIDE: Leads to a controlled weakening of the connections between the cells. Therefore, it reproduces the process of scaling typical of young skin.

PHA: Present in the skin is important in the processes of cell renewal, has strong moisturizing capacity, modulates the process of keratinization, revitalizes cell turnover, it is also an antioxidant against ROS, improves skin barrier function, especially in sensitive skin and protects against photoaging.

AHAs (Cycle-system): They are activators of the mechanisms that regulate cellular energy metabolism of dermal and -epidermal cells (energizing).

MALIC ACID: Acts as a catalyst in the Krebs’ cycle to, stimulate the complete combustion of fuel for energy.

RETINAL: Breaks down into retinoic acid and implements a real cellular reprogramming through actions of genes involved in repression and derepression.

G-FACTOR P63 – exclusively Natinuel: Activates the differentiation of stem cells, promotes angiogenesis, increases the biosynthesis of collagen, elastin, proteoglycans and GAGs, stimulates the self-repair mechanisms of the skin, rebuilds the protective barrier of the skin, counteracts the glycation of proteins, activates the removal of damaged skin proteins and activated protein antioxidants such as SOD, inhibits MMPs, blocks the activity of ‘interleukin-1.

IDEBENON : Has a double action: blocks and eliminates free radicals generated by the environment, neutralizes free radicals generated internally, improves oxygenation and cellular energy.

SURVIXYL Pentapeptide-31: A next-generation peptide that is a result of the latest discoveries in the field of stem cell research and is specifically designed to address five major factors that regulate the biological activity of the stem cells of the skin. It helps strengthen and preserve the microenvironment of stem cells and optimize epidermal rejuvenation.

Is a fl uid milk, based on dermo-compatible light oil-in-water emulsion, which creates a non-occlusive barrier on the whole skin in order to slow down the water loss by evaporation. The milk was also enriched with natural substances having soothing and decongestant properties. The product is indicated for an optimal make-up removal, even in the eye area. It is non-irritating and can also be used on delicate and sensitive skin.

After rinsing the milk all the make-up particles will be eliminated and the skin will be made ready for cleansing.

VITAMIN E: A fat-soluble molecule associated with biological membranes and lipoproteins, it protects polyunsaturated fats from peroxiadation.

AVOCAD OIL: Thanks to very high content of unsaponifi ables, avocado oil has unique eudermic and sebum-like properties and forms a protective fi lm on the surface of the skin. It performs surface restoring action when applied to matt, dry and dehydrated skin.

CHAMOMILE EXTRACT: Emollient, protective, purifying action.

MARIS AQUA: Revitalizing, tonifying.

ALOE VERA: It is a great moisturizer for the skin, due to its content of polysaccharides it creates a barrier that prevents Transepidermal Water Loss.

AVENA SATIVA – OAT OIL: Emollient, soothing properties.

Is an innovative cream based on ozonides integrated with a special peptide, this particular type of synergy makes the skin tissue more oxygenated and moisturized. Once applied to the skin OXY100 frees nascent oxygen which combines with hemoglobin to oxygenate the tissues. This particular speeds up the healing of skin lesions,improves wound healing and reactivates and reorganizes multiple metabolic mechanisms that are fundamental for a healthy and biologically younger skin.

It increases tissue oxygenation, increases the ATP, improves the repair of wounds and skin lesions of various kinds, has sanitizing properties, improves healing, strengthens the skin’s natural defenses, stimulates various metabolic processes, improves the vascularization of regenerated tissues.

OZONIDES: The ozonides are a special mixture of oil and ozone which provides the skin with stable ozone enabling the skin to to exploit fully its peculiar and multiple propertiesIt revitalizes cellular metabolism, improves microcirculation and oxygenation of tissues.

BIO-PEPTIDE: It improves the production of collagen, elastin, proteoglycans, glycosaminoglycans and other components of the skin matrix. It enhances various catabolic processes, restrains the process called glycation, regulates MMPs, enhances endogenous antioxidant system, improves the vascularization of the skin, counteracts the skin inflammation (through blockade of interleukin-1.

A new multifunctional bioceutic, able to intervene in a new way on the biochemical mechanisms responsible for the production of melanin, to favor an optimal fibroblastic bio-activity, and to guarantee a strong anti-oxidant action against free radicals. But PERFECT C is also able to give an immediate aesthetic improvement with a beautiful make-up effect and with an evident compactness and uniformity of the skin surface.

AESTHETIC IMPROVEMENT
• Uniforms the complexion of the complexion.
• Immediately covers skin imperfections.
• Provides an ideal make-up based on the individual skin tone.

FUNCTIONAL IMPROVEMENT
• Extensive regularization of the biochemical mechanisms that determine production of melanin.
• Bio-protective action against free radicals.
• Promotes the bio-activity of fibroblasts.
• It gives the skin an adequate photoprotection.
• Reduces skin irritations.

UNDECYLENOYL PHENYLALANINE: Performs its action as a cell receptor antagonist for MSH (MC1R). A strong regularization action on the hyperproduction of melanin and an increase in skin brightness.

ACETYL GLOSHOSAMINE: Inhibits the glycosylation process necessary to switch from inactive to active tyrosinase.

RETINALDEHYDE: Vitamin A derivatives, retinoic acid, play a role in reducing the transcription process of the tyrosinase gene.

ARBUTINE: It works by reducing the activity of tyrosinase.

SOYBEAN TRIPSIN: Reduces the activity of PAR2 receptors that allow the entry of melanosomes into keratinocytes.

VC-IP: Improved absorption capacity, inhibits tyrosinase activity and melanogenesis Protects DNA from UV damage. It prevents the lipopredoxidation of cell membranes, improves the synthesis of collagen and its protection.

VIT PP (Nicotinamide): Improves cellular communication, stimulates microcirculation in the dermis, improves skin elasticity, reinforces barrier function. Helps to correct skin hyperpigmentation, improves tone and consistency of the skin. Helps to reduce wrinkles, promotes the normalization of acne skin. TGP2 (Oligopeptide 34): Melanin synthesis decreases through the regulation of TRP-1, TRP- 2, MITF and Tyrosinase, blocks the transfer of melanosoma from melanocyte to keratinocyte. TGP2, has an anti-inflammatory effect thanks to the “down regulation” of TH1-type pro- inflammatory cytokines.

SOLAR FILTERS: Mix of balanced filters for medium protection.

MAGIC COLOR: Particular complex of pigments able to adapt to the different skin color of a person and guarantee a natural homogeneous make up with an optimal covering skin imperfections.

A multifunctional bioceutical preparation capable of guaranteeing high protection and prividing an effective shield against UVA and UVB together with reinforcement of the skin barrier and strong antioxidant properties enabling biological protection of cell structures in the various layers of the skin. This product is suitable for all skin types including sensitive and delicate, in particular those which are at risk of hyperpigmentation. We recommend the use all year round even in winter, because it protects the skin barrier from the harsh climatic conditions even the most extreme.

• High protection against UVA-UVB rays. Strong protection of bio-cellular structures.
• Strong antioxidant and soothing properties. Improves the uniformity of the skin tone.
• It prevents the formation of hyperpigmented spots. Strengthens the skin barrier to protect it against harsh climatic conditions.

Photostability is the ability of a molecule to remain intact when exposed to solar radiation and toxicity of sunscreens. The filters are substances deliberately chosen from among those able to absorb and convert the energy of ultraviolet radiation. However, during this process a non-photostable filter undergoes structural changes which alter the filtering characteristics and the protective capacity and can determine the release of several photoproducts of degradation,which may be harmful to the skin.

PARSOL MCX: A chemical filter with high solubility and photostability able to screen out UVB rays reduces sunburn immediately, preventing damage to the DNA of keratinocytes and melanocytes and carcinogenesis.

TINOSORB M: Hybrid compound combining the properties of physical and chemical filters. It implements a new technology to protect the skin against UV rays. It is a hybrid UV absorber, the only organic UV filter produced as microfine organic particles. Tinosorb M is intrinsically photostable and offers broad spectrum protection against both harmful UVA and UVB rays.

UNIPURE WHITE: Titanium dioxide provides natural protection against UVA and UVB rays. The cream is safe to use and does not cause irritation. It is based on a mechanism of light reflection.

APEROXID COMPLEX: Synergistic blend of antioxidants provides a strong bio-protection from free radicals induced by UV rays.

SHEA BUTTER: It has strong emollient, moisturizing, soothing, re-epithelizing, properties which help to preserve the skin barrier.

Is a specific product for skin with excessive oiliness and acne. In contains selected active ingredients with bio-chemical properties complementary to one other, which normalize the excessive sebum secretions, it has antibacterial, keratolytic, soothing and sanitizing properties. These multiple activities create hygienic and functional conditions which, are ideal for regression and normalization of oily skin and acne.a specific product for skin with excessive oiliness and acne.

It normalizes the abnormal follicular keratinization, removes blackheads, normalizes excessive sebum secretion, promotes regression of acne phenomena, has strong sanitizing properties, reduces inflammation, helps the skin to regain its integrity and functionality.

SEBO-SOFT: A compound of sodium polyacrylate and sebacic acid. The sebacic acid, have a similar properties azelaic acid . It has a strong antimicrobial properties and ability to reduce the hyperkeratinization of follicle. Sebo-soft is able to quickly lock the Propionibacterium Acnes and at the same time, prevent undesirable effects, often found in many anti-acne products such as: dehydration and skin irritation . Sebo-soft helps normalize the hydro-lipid film and helps restore a physiological surface hydration.

A.C. NET COMPLEX: Association of oleanolic acid and nordihydroguaiaretic acid (NDGA) in an osmotic gel. Oleanolic acid inhibits 5-α reductase to fight hyperseborrhoea. NDGA is a cell growth regulator that inhibits hyperkeratosis and inflammation. The osmotic gel helps to control bacterial growth.

SALICYLIC ACID: It acts as a keratolytic breaking selectively, the keratin protein chain present in the corneocytes. Because it has no effect on other proteins, this substance destroys and only exfoliates the horny cells, it’s therefore well tolerated by cells below, without keratin. The Salicylic acid, penetrates in the inflamed lesions, where it has a desiccant and antibacterial action, it is also applicable in the acute inflammation.

GLYCOLIC ACID: Reduces cellular cohesion between corneocytes, restores a physiological epidermal cell turnover, prevents the formation and helps remove blackheads.

MANDELIC ACID: Slowly penetrates into the skin, has bacteriostatic and sebostatic property at the pilosebaceous follicle level .The mandelic acid is an AHAs, promotes without causing irritation and burning cell turnover and renewal of the epidermis. SEBOSOFT: It helps normalize the hydro-lipid film and helps restore a physiological surface hydration.

VIT PP: Anti-inflammatory, antibiotic property (comparable to clindamycin but does not create antibiotic resistance ), sebum regulating. It helps restore a physiological surface hydration.

ALLANTOIN: Defined as “cell- proliferant because oversees the formation of epithelial tissue. It has properties: keratoplasty, emollient, soothing, antioxidant.

Is a gel shown to regulate the melanogenesis process and eliminate skin hyper- pigmentation. Its formula showing high biochemical activity has been designed to work effectively at various levels, inhibit and regulate the production of melanin, facilitate removal of hyper-pigmented cells. It helps to even the skin tone and protects the skin from the factors causing the problem. Using the product on regular basis quickly normalizes the color of the skin and gradually penetrates into the deeper layers of the skin eliminating the problem at its roots.

It favors the gradual elimination of the hyper-pigmented cells and helps to even the skin color. It confers broad spectrum protection, fights the inflammatory processes by reducing the risk of hyper-pigmentation.

TGP 2 (Oligopeptide -34): Decreases melanin synthesis through the regulation of TRP-1, TRP- 2, MITF and Tyrosine. Blocks the transfer of melanosome from melanocyte to keratinocyte. It has an anti-inflammatory effect due to “down regulation” of pro-inflammatory cytokines of TH1 type.

PEEL MOIST: It ‘a molecular film which reduces the roughness and dryness increasing desquamation and moisturizing the skin naturally. Improves scaling of keratinocytes, it contains ions and amino acids of the NMF, lafunzione maintaining skin barrier. Hydration immediate and durable. Editor’s login Peel Moist gives the skin softness, brightness, uniform color.

MELANOSTATINE (Nonapeptide -1): It has an antagonistic action of alpha-MSH (MELANOCYTE- ALFA – STIMOLANTE), competes with the natural ligand (alpha-MSH) on its specific receptor (MC1-R) by preventing the activation of tyrosinase and then blocking the synthesis of melanin. The inhibition of tyrosinase reduces the formation of unwanted pigmentation.

ETIOLINE: It inhibits the activity of tyrosinase, balances the synthesis of melanin.

Is a new generation bioceutical preparation showing strong activity. THE LOOK impacts various imperfections of the eye area such as: skin tone, facial wrinkles, dark circles under the eyes, eyebags and hydration. This product ideal for a complete renovation and rejuvenation of the whole area around the eyes. significant reduction in the frequency of muscle contractions, decreased expression wrinkles, elimination of fine lines, reduction of eyebags and dark circles, skin becomes firmer, more compact and better moisturized.

Significant reduction in the frequency of muscle contractions, decreased expression wrinkles, elimination of fine lines, reduction of eyebags and dark circles, skin becomes firmer, more compact and better moisturized.

VIALOX (Pentapeptide -3) + ARGIRELINE (Hexapeptide -8): They interact synergistically on the biochemical mechanisms of muscle contraction significantly reducing mimic wrinkles.

INYLINE (Pentapeptide -3): It acts on the postsynaptic membrane by inhibiting the complex Agrin / MASC Thus preventing the clustering of receptors AChRs. None of this can trigger the biochemical phase post-synaptic and you get a result in a net reduction of mimic wrinkles.

SYN-COLL (Palmitoyl Tripeptide -3): This peptide strongly stimulates the neoproduction collagen and elastin. It also protects collagen by inhibiting the enzymatic degradation (MMPs 1 and MMPs 3), and block proinflammatory cytokines.

EYELISS (Hesperidin Methyl Chalcone, Dipeptide -2, Tetrapeptide- 7): It improves capillary fragility and regulates their permeability. Eliminates material build-up of metabolic waste and liquid, and that ‘the main cause of bags under the eyes, improves lymphatic drainage, the exchange and the movement of extra-cellular fluids. It acts on the inflammatory component and sagging skin, improving firmness elasticita’e tone to the skin.

HALOXYL (Oligopeptide, Tripeptide -3, Crisina Complex): Complex specifically to eliminate the accumulation of by-products of oxidized hemoglobin, with a clear and steady reduction of dark circles under the eyes. It also strengthens the capillaries, preventing leakage and accumulation of emoglobin. It has a strong anti-inflammatory action by inhibiting prostaglandin PGE2 improves the tone and firmness of the skin that helps to even out the color under the eyes.

QUINTESCINE (Dipeptide – 4): Bio-protector broad range, protects the skin from oxidative stress, improves the natural defense mechanisms against oxidative stress (SOD and catalase), reduces carbonylation protein, improves the protection of DNA, decreases peroxidation of lipids, protects against damage glycation.